The Journal of infectious diseases · 2021
Molecular Epidemiology of Mansonella Species in Gabon.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sandri Thaisa Lucas, Kreidenweiss Andrea, Cavallo Simon, Weber David, Juhas Sascha, Rodi Miriam, Woldearegai Tamirat Gebru, Gmeiner Markus, Veletzky Luzia, Ramharter Michael, Tazemda-Kuitsouc Gildas B, Matsiegui Pierre Blaise, Mordmüller Benjamin, Held Jana
Аннотация
Mansonella perstans, a filarial nematode, infects large populations in Africa and Latin America. Recently, a potential new species, Mansonella sp "DEUX," was reported. Carriage of endosymbiotic Wolbachia opens treatment options for Mansonella infections. Within a cross-sectional study, we assessed the prevalence of filarial infections in 834 Gabonese individuals and the presence of the endosymbiont Wolbachia. Almost half of the participants (400/834 [48%]) were infected with filarial nematodes, with Mansonella sp "DEUX" being the most frequent (295/400 [74%]), followed by Loa loa (273/400 [68%]) and Mansonella perstans (82/400 [21%]). Being adult/elderly, male, and living in rural areas was associated with a higher risk of infection. Wolbachia carriage was confirmed in M. perstans and Mansonella sp "DEUX." In silico analysis revealed that Mansonella sp "DEUX" is not detected with currently published M. perstans-specific assays. Mansonella infections are highly prevalent in Gabon and might have been underreported, likely also beyond Gabon.