Leukemia & lymphoma · 2016
Serum soluble interleukin-2 receptor level at diagnosis predicts transformation in patients with follicular lymphoma.
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Umino Kento, Fujiwara Shin-Ichiro, Ito Shoko, Mashima Kiyomi, Minakata Daisuke, Nakano Hirofumi, Yamasaki Ryoko, Kawasaki Yasufumi, Sugimoto Miyuki, Ashizawa Masahiro, Hatano Kaoru, Okazuka Kiyoshi, Sato Kazuya, Oh Iekuni, Ohmine Ken, Suzuki Takahiro, Muroi Kazuo, Kanda Yoshinobu
Аннотация
We evaluated 121 patients with follicular lymphoma (FL) and analyzed the association between the soluble interleukin-2 receptor (sIL-2R) level at diagnosis and the cumulative incidence of transformation. By a receiver-operating characteristic analysis, we determined a cutoff value of sIL-2R for transformation at 4360 U/mL to classify patients into two groups. Patients in the high sIL-2R group showed a shorter progression-free survival (PFS) and shorter disease-specific survival (DSS) (p < 0.001 and p = 0.018). Furthermore, the cumulative incidence of transformation in the high sIL-2R group was higher than that in the low sIL-2R group (40.9% vs. 7.3% at 5 years, p < 0.001). In a multivariate analysis, high sIL-2R was an independent predictive risk factor for transformation (HR 7.42, 95% CI: 2.75-20.0, p < 0.001). This study showed that the sIL-2R level at diagnosis may be a prognostic factor for transformation, PFS, and DSS in patients with FL.