Inflammopharmacology · 2007
Interaction of VEGF to gastric low grade MALT lymphoma by Helicobacter heilmannii infection in C57/BL/6 mice.
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Nakamura M, Matsui H, Murayama S Yamagata, Matsumoto T, Yamada H, Takahashi S, Tsuchimoto K
Аннотация
UNLABELLED: Helicobacter heilmannii (Hh) has been clinically reported to have some relation to gastric low grade MALT lymphoma. Recently, we have formed the gastric MALT lymphoma in C57BL/6 mice.
MATERIALS AND METHODS: C57BL/6 mice infected with Hh from cynomolgus monkey for more than 6 months were used. The macroscopic, immunohistochemical and electron microscopic observation was performed
RESULTS: MALT lymphoma was formed in almost 100% of the infected mice. Increased VEGF-A and Flt-3 immunoreactivity was recognized.
CONCLUSION: Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.
MATERIALS AND METHODS: C57BL/6 mice infected with Hh from cynomolgus monkey for more than 6 months were used. The macroscopic, immunohistochemical and electron microscopic observation was performed
RESULTS: MALT lymphoma was formed in almost 100% of the infected mice. Increased VEGF-A and Flt-3 immunoreactivity was recognized.
CONCLUSION: Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.