Future oncology (London, England) · 2022
Process, resource and success factors associated with chimeric antigen receptor T-cell therapy for multiple myeloma.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hoda Daanish, Richards Robert, Faber Edward A, Deol Abhinav, Hunter Bradley D, Weber Elizabeth, DiFilippo Heather, Henderson-Clark Toni, Meaux Linda, Crivera Concetta, Riccobono Carrie, Garrett Ashraf, Jackson Carolyn C, Fowler Jessica, Theocharous Panteli, Stewart Raj, Lorden Andrea L, Porter David L, Berger Ariel
Аннотация
Background: Chimeric antigen receptor T-cell (CAR-T) therapy represents a new frontier in multiple myeloma. It is important to understand critical success factors (CSFs) that may optimize its use in this therapeutic area. Methods: We estimated the CAR-T process using time-driven activity-based costing. Information was obtained through interviews at four US oncology centers and with payer representatives, and through publicly available data. Results: The CAR-T process comprises 13 steps which take 177 days; it was estimated to include 46 professionals and ten care settings. CSFs included proactive collaboration, streamlined reimbursement and CAR-T administration in alternative settings when possible. Implementing CSFs may reduce episode time and costs by 14.4 and 13.2%, respectively. Conclusion: Our research provides a blueprint for improving efficiencies in CAR-T therapy, thereby increasing its sustainability for multiple myeloma.