Anticancer research · 2006
Serum interleukin-6 levels in patients with gastric MALT lymphoma compared to gastric and pancreatic cancer.
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Bartsch Rupert, Woehrer Stefan, Raderer Markus, Hejna Michael
Аннотация
BACKGROUND: Interleukin-6 (IL-6) plays a major role in inflammatory processes and various malignancies. Serum IL-6 levels from patients with gastric MALT lymphoma, gastric cancer and pancreatic cancer was investigated.
PATIENTS AND METHODS: The serum 11-6 levels were obtained in a total of 86 patients. A two-tailed Mann-Whitney-test was performed to compare the results. A p-level <0.05 was deemed statistically significant.
RESULTS: In lymphoma patients, the mean IL-6 levels were 12.633 pg/ml (SD 10.465). The levels for gastric cancer were 6.324 pg/ml (SD 11.497) and 27.4 pg/ml (SD 86.272) for pancreatic cancer. A comparison between MALT lymphoma and gastric cancer revealed a significant difference (p=0.0030), while no difference was found between MALT lymphoma and pancreatic cancer. The 11-6 levels, however, were higher in pancreatic cancer than gastric cancer (p =0.0040).
CONCLUSION: Our results might reflect a greater importance of IL-6 in the development and growth of MALT lymphoma and, possibly, pancreatic cancer than in gastric cancer.
PATIENTS AND METHODS: The serum 11-6 levels were obtained in a total of 86 patients. A two-tailed Mann-Whitney-test was performed to compare the results. A p-level <0.05 was deemed statistically significant.
RESULTS: In lymphoma patients, the mean IL-6 levels were 12.633 pg/ml (SD 10.465). The levels for gastric cancer were 6.324 pg/ml (SD 11.497) and 27.4 pg/ml (SD 86.272) for pancreatic cancer. A comparison between MALT lymphoma and gastric cancer revealed a significant difference (p=0.0030), while no difference was found between MALT lymphoma and pancreatic cancer. The 11-6 levels, however, were higher in pancreatic cancer than gastric cancer (p =0.0040).
CONCLUSION: Our results might reflect a greater importance of IL-6 in the development and growth of MALT lymphoma and, possibly, pancreatic cancer than in gastric cancer.