American journal of ophthalmology · 2006
Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue lymphoma.
Клинический случайСтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод пока не подготовлен
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Shen Defen, Yuen Hunter K L, Galita Dan A, Chan Nongnart R, Chan Chi-Chao
Аннотация
PURPOSE: To detect Chlamydia pneumoniae (C. pneumoniae) gene in a patient with bilateral orbital musoca-associated lymphoid tissue (MALT) lymphoma.
DESIGN: Interventional case report.
METHODS: A 47-year-old Chinese man with recurrent bilateral orbital masses underwent surgical biopsy. Ophthalmologic and radiographic examinations, routine histology, immunohistochemistry, and molecular analysis for immunoglobulin heavy chain (IgH), bcl-2/IgH gene translocation, and Chlamydia genes were performed.
RESULTS: Pathology revealed orbital MALT lymphoma with B-cell monoclonality. In addition to IgH gene rearrangement, C. pneumoniae DNA was detected in the lymphoma.
CONCLUSIONS: The finding of C. pneumoniae molecular signatures in this case suggests a possible association of Chlamydia and orbital MALT lymphoma. The infection may contribute to the development of the lymphoma.
DESIGN: Interventional case report.
METHODS: A 47-year-old Chinese man with recurrent bilateral orbital masses underwent surgical biopsy. Ophthalmologic and radiographic examinations, routine histology, immunohistochemistry, and molecular analysis for immunoglobulin heavy chain (IgH), bcl-2/IgH gene translocation, and Chlamydia genes were performed.
RESULTS: Pathology revealed orbital MALT lymphoma with B-cell monoclonality. In addition to IgH gene rearrangement, C. pneumoniae DNA was detected in the lymphoma.
CONCLUSIONS: The finding of C. pneumoniae molecular signatures in this case suggests a possible association of Chlamydia and orbital MALT lymphoma. The infection may contribute to the development of the lymphoma.
Предметные рубрики MeSH
Antineoplastic Agents, AlkylatingChlamydophila InfectionsChlamydophila pneumoniaeChlorambucilDNA, BacterialEye Infections, BacterialGene RearrangementGenes, BacterialGenes, ImmunoglobulinGlucocorticoidsHumansImmunoglobulin Heavy ChainsLymphoma, B-Cell, Marginal ZoneMaleMiddle AgedOrbital NeoplasmsPolymerase Chain ReactionPrednisoneProto-Oncogene Proteins c-bcl-2Tomography, X-Ray Computed