Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort.
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Huerta José María, Navarro Carmen, Chirlaque María-Dolores, Tormo María-José, Steindorf Karen, Buckland Genevieve, Carneiro Fátima, Johnsen Nina Føns, Overvad Kim, Stegger Jakob, Tjønneland Anne, Boutron-Ruault Marie-Christine, Clavel-Chapelon Françoise, Morois Sophie, Boeing Heiner, Kaaks Rudolf, Rohrmann Sabine, Vigl Matthäus, Lagiou Pagona, Trichopoulos Dimitrios, Trichopoulou Antonia, Bas Bueno-de-Mesquita H, Monninkhof Evelyn M, Numans Mattijs E, Peeters Petra H, Mattiello Amalia, Pala Valeria, Palli Domenico, Tumino Rosario, Vineis Paolo, Agudo Antonio, Ardanaz Eva, Arriola Larraitz, Molina-Montes Esther, Rodríguez Laudina, Lindkvist Björn, Manjer Jonas, Stenling Roger, Lund Eiliv, Crowe Francesca L, Key Timothy J, Khaw Kay-Tee, Wareham Nicholas J, Jenab Mazda, Norat Teresa, Romaguera Dora, Riboli Elio, González Carlos A
Аннотация
METHODS: From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse).
RESULTS: During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling. The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50-0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26-0.74, for non-cardia GAC). No effect was found for cardia tumours or histological subtypes of GAC. PA of any kind was not associated with OAC.
CONCLUSIONS: Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach.