Magma (New York, N.Y.) · 2026
Trans-cytolemmal water exchange in prostate manifest via DCE-MRI.
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Li Xin, Kopp Ryan P, Rooney William D, Springer Charles S, Coakley Fergus V, Garzotto Mark G
Аннотация
OBJECTIVE: To investigate the potential of the unidirectional cellular water efflux rate constant (kio) from DCE-MRI data in prostate MR imaging.
MATERIALS AND METHODS: High-temporal-resolution prostate DCE-MRI data were modeled using both the fast-exchange-limit (FXL) Tofts' model as well as the water-exchange-sensitized shutter-speed model (SSM). In the SSM, kio was included as an additional fitting parameter. Lesion and normal-appearing (NA) prostate tissue region-of-interest (ROI) data were analyzed and categorized into FXL or non-FXL conditions based on results from the two models. A global upper limit of kio detectable by prostate DCE-MRI with the SSM was presented.
RESULTS: While many lesion voxels exhibited sensitivity to kio with the SSM, a substantial portion remained in the FXL condition despite greater contrast agent extravasation than in NA tissue. The fraction of FXL voxels was higher in lesions than in NA tissue. Applying a global detectable kio upper limit increased the difference between lesion and NA ROIs, improving lesion characterization.
DISCUSSION: SSM-derived FXL and non-FXL contrasts may serve as novel imaging biomarkers for prostate cancer surveillance. Advances in MRI technology and more potent contrast agents are expected to enhance the accuracy of kio quantification, potentially enabling its integration into clinical mpMRI.
MATERIALS AND METHODS: High-temporal-resolution prostate DCE-MRI data were modeled using both the fast-exchange-limit (FXL) Tofts' model as well as the water-exchange-sensitized shutter-speed model (SSM). In the SSM, kio was included as an additional fitting parameter. Lesion and normal-appearing (NA) prostate tissue region-of-interest (ROI) data were analyzed and categorized into FXL or non-FXL conditions based on results from the two models. A global upper limit of kio detectable by prostate DCE-MRI with the SSM was presented.
RESULTS: While many lesion voxels exhibited sensitivity to kio with the SSM, a substantial portion remained in the FXL condition despite greater contrast agent extravasation than in NA tissue. The fraction of FXL voxels was higher in lesions than in NA tissue. Applying a global detectable kio upper limit increased the difference between lesion and NA ROIs, improving lesion characterization.
DISCUSSION: SSM-derived FXL and non-FXL contrasts may serve as novel imaging biomarkers for prostate cancer surveillance. Advances in MRI technology and more potent contrast agents are expected to enhance the accuracy of kio quantification, potentially enabling its integration into clinical mpMRI.