Head & neck · 2016
Predictors of survival in parotid adenocarcinoma not otherwise specified: a National Cancer Database study of 3155 patients.
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Zhan Kevin Y, Huang Andrew T, Khaja Sobia F, Bell Diana, Day Terry A
Аннотация
BACKGROUND: Parotid adenocarcinoma not otherwise specified (PANOS) is a common parotid cancer, but studies specifically on this subject are limited.
METHODS: We conducted a retrospective review of the National Cancer Database.
RESULTS: Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with high-grade histology (67.2%). Regional metastasis was common (35.9%), whereas occult nodal metastasis (20.2% overall) was less frequent in non-high-grade lesions (8.5% vs 31.6%; p < .001). Distant metastasis was rare (7.9%). Five-year overall survival (OS) was 47%. In multivariate analysis, age, regional metastasis, distant metastasis, high-grade, and T classification were predictors of lower survival. Patients with stage III to IV disease receiving surgery and radiotherapy had a better OS than those receiving surgery alone (51% vs 41%; p < .001).
CONCLUSION: PANOS is an aggressive disease with frequent regional metastasis and low survival. Numerous variables are associated with worse survival. © 2016 Wiley Periodicals, Inc. Head Neck 38:1208-1212, 2016.
METHODS: We conducted a retrospective review of the National Cancer Database.
RESULTS: Ten percent of all parotid cancers were PANOS (n = 3155). Median age was 67 years. Most patients were men (62.8%) with high-grade histology (67.2%). Regional metastasis was common (35.9%), whereas occult nodal metastasis (20.2% overall) was less frequent in non-high-grade lesions (8.5% vs 31.6%; p < .001). Distant metastasis was rare (7.9%). Five-year overall survival (OS) was 47%. In multivariate analysis, age, regional metastasis, distant metastasis, high-grade, and T classification were predictors of lower survival. Patients with stage III to IV disease receiving surgery and radiotherapy had a better OS than those receiving surgery alone (51% vs 41%; p < .001).
CONCLUSION: PANOS is an aggressive disease with frequent regional metastasis and low survival. Numerous variables are associated with worse survival. © 2016 Wiley Periodicals, Inc. Head Neck 38:1208-1212, 2016.
Предметные рубрики MeSH
AdenocarcinomaAdultAgedAged, 80 and overCohort StudiesCombined Modality TherapyDatabases, FactualDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNational Cancer Institute (U.S.)Neoplasm InvasivenessNeoplasm StagingParotid GlandParotid NeoplasmsPrognosisProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeUnited States