Pediatric gastroenterology, hepatology & nutrition · 2025
Comparison of Duodenal Strictures Between Crohn's and Non-Crohn's Diseases in Children.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Youn Ji Won, Hahn Jong Woo, Yang Hye Ran
Аннотация
PURPOSE: This study aimed to compare the clinical features and laboratory findings of duodenal strictures caused by Crohn's disease (CD) with those of other etiologies in children.
METHODS: We recruited children diagnosed with duodenal strictures through a full investigation. Clinical, laboratory, endoscopic, and radiological data at diagnosis were collected retrospectively.
RESULTS: Of the 11 included patients, four were diagnosed with CD, four with eosinophilic gastrointestinal disorder (EGID), and the other three were grouped together (Helicobacter-associated in one and idiopathic disease in two). Serum anti-Saccharomyces cerevisiae antibody (ASCA) was positive in four of four (100%) CD cases, four of four (100%) EGID cases, and none (0%) of the other cases (p=0.011). The median fecal calprotectin concentration was 994 mg/kg in the CD group (range: 626-2,118 mg/kg), 548 mg/kg in the EGID group (range: 458-1,056 mg/kg), and 124 mg/kg in one patient in the other group (p=0.313). Surgery for duodenal obstruction was performed in four patients (one with CD and three with idiopathic and Helicobacter-associated conditions) (p=0.021), and balloon dilation was performed in one patient with CD and one other patient.
CONCLUSION: Although acquired duodenal strictures are rare in children, they can develop in pediatric patients with CD or EGID. The measurement of serum ASCA and fecal calprotectin levels before endoscopic and histopathological investigations may identify the presence of organic causes of duodenal strictures in children.
METHODS: We recruited children diagnosed with duodenal strictures through a full investigation. Clinical, laboratory, endoscopic, and radiological data at diagnosis were collected retrospectively.
RESULTS: Of the 11 included patients, four were diagnosed with CD, four with eosinophilic gastrointestinal disorder (EGID), and the other three were grouped together (Helicobacter-associated in one and idiopathic disease in two). Serum anti-Saccharomyces cerevisiae antibody (ASCA) was positive in four of four (100%) CD cases, four of four (100%) EGID cases, and none (0%) of the other cases (p=0.011). The median fecal calprotectin concentration was 994 mg/kg in the CD group (range: 626-2,118 mg/kg), 548 mg/kg in the EGID group (range: 458-1,056 mg/kg), and 124 mg/kg in one patient in the other group (p=0.313). Surgery for duodenal obstruction was performed in four patients (one with CD and three with idiopathic and Helicobacter-associated conditions) (p=0.021), and balloon dilation was performed in one patient with CD and one other patient.
CONCLUSION: Although acquired duodenal strictures are rare in children, they can develop in pediatric patients with CD or EGID. The measurement of serum ASCA and fecal calprotectin levels before endoscopic and histopathological investigations may identify the presence of organic causes of duodenal strictures in children.