JHEP reports : innovation in hepatology · 2026
The impact of alcohol consumption on the risk of hepatocellular carcinoma across different age groups: A nationwide cohort study.
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Kim Mi Na, Han Kyungdo, Kim Dong Yun, Lee Jae Seung, Lee Hye Won, Kim Beom Kyung, Kim Seung Up, Park Jun Yong, Ahn Sang Hoon, Kim Do Young
Аннотация
BACKGROUND & AIMS: Alcohol consumption is a well-established risk factor for hepatocellular carcinoma (HCC), although its impact may vary across different age groups. Accordingly, we aimed to investigate the association between alcohol consumption and the risk of HCC across different age groups.
METHODS: We included 4,234,445 participants aged ≥20 years who underwent a national health examination in 2009. Cox proportional hazards regression models were used to investigate the association of alcohol consumption with the risk of HCC across age groups.
RESULTS: Among 3,869,084 participants, 20,475 individuals were newly diagnosed with HCC during a median follow-up of 11.3 years. When stratified by 20-years age groups, increasing alcohol consumption was significantly associated with an increased risk of HCC in the ≥60-years age group compared with no alcohol consumption (p for trend <0.001). Heavy alcohol consumption was significantly associated with an increased risk of HCC in the 40-59-years and ≥60-years age groups, with larger effect estimates observed at older ages (adjusted hazard ratio, 1.11; 95% CI, 1.05-1.18 for the 40-59-years age group; adjusted hazard ratio, 1.47; 95% CI, 1.38-1.57 for the ≥60-years age group).
CONCLUSIONS: Our findings indicate that the association between alcohol consumption and the risk of HCC differs across age groups, with the most pronounced risk increase observed among older individuals. These findings may inform age-tailored HCC risk assessment and prevention strategies, particularly by identifying middle-aged and older heavy drinkers who may benefit from more careful risk stratification.
IMPACT AND IMPLICATIONS: Alcohol consumption is a well-established risk factor for HCC, but its age-specific impact remains insufficiently defined. In this nationwide cohort of 3,869,084 adults, heavy alcohol consumption was associated with increased HCC risk in the 40-59-years and ≥60-years age groups, with the strongest association and highest 10-year cumulative risk observed among heavy drinkers aged ≥60 years. These findings may help refine age-tailored HCC risk assessment by supporting the consideration of heavy alcohol consumption alongside established liver-related risk factors, particularly in middle-aged and older adults.
METHODS: We included 4,234,445 participants aged ≥20 years who underwent a national health examination in 2009. Cox proportional hazards regression models were used to investigate the association of alcohol consumption with the risk of HCC across age groups.
RESULTS: Among 3,869,084 participants, 20,475 individuals were newly diagnosed with HCC during a median follow-up of 11.3 years. When stratified by 20-years age groups, increasing alcohol consumption was significantly associated with an increased risk of HCC in the ≥60-years age group compared with no alcohol consumption (p for trend <0.001). Heavy alcohol consumption was significantly associated with an increased risk of HCC in the 40-59-years and ≥60-years age groups, with larger effect estimates observed at older ages (adjusted hazard ratio, 1.11; 95% CI, 1.05-1.18 for the 40-59-years age group; adjusted hazard ratio, 1.47; 95% CI, 1.38-1.57 for the ≥60-years age group).
CONCLUSIONS: Our findings indicate that the association between alcohol consumption and the risk of HCC differs across age groups, with the most pronounced risk increase observed among older individuals. These findings may inform age-tailored HCC risk assessment and prevention strategies, particularly by identifying middle-aged and older heavy drinkers who may benefit from more careful risk stratification.
IMPACT AND IMPLICATIONS: Alcohol consumption is a well-established risk factor for HCC, but its age-specific impact remains insufficiently defined. In this nationwide cohort of 3,869,084 adults, heavy alcohol consumption was associated with increased HCC risk in the 40-59-years and ≥60-years age groups, with the strongest association and highest 10-year cumulative risk observed among heavy drinkers aged ≥60 years. These findings may help refine age-tailored HCC risk assessment by supporting the consideration of heavy alcohol consumption alongside established liver-related risk factors, particularly in middle-aged and older adults.