Annals of surgical oncology · 2025
Tumor Radioactivity in 99mTc-GSA Scintigraphy Predicts Oncological Outcomes in Patients Who Underwent Hepatectomy for Hepatocellular Carcinoma.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Furukawa Kenei, Haruki Koichiro, Watanabe Ken, Gomisawa Kazutaka, Shimoda Masayuki, Onda Shinji, Shirai Yoshihiro, Matsumoto Michinori, Tsunematsu Masashi, Ikegami Toru
Аннотация
BACKGROUND: Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin (99mTc-GSA) scintigraphy is used as a preoperative liver reserve test. This study investigated whether tumor radioactivity in 99mTc-GSA scintigraphy correlates with the survival of patients with hepatocellular carcinoma (HCC).
PATIENTS AND METHODS: In total, 115 patients who underwent 99mTc-GSA scintigraphy before hepatectomy for HCC were included in this study. Tumor radioactivity in 99mTc-GSA scintigraphy was assessed, and its prognostic relevance to disease-free survival (DFS) and overall survival (OS) in patients with HCC was evaluated.
RESULTS: The hepatic uptake index in 99mTc-GSA scintigraphy was associated with liver fibrosis. HCC with high tumor radioactivity in 99mTc-GSA scintigraphy showed high expression of the asialoglycoprotein receptor. Tumor radioactivity in 99mTc-GSA scintigraphy was associated with histologic differentiation grade and tumor size. Low tumor radioactivity was identified as an independent poor prognostic predictor of both DFS and OS.
CONCLUSIONS: 99mTc-GSA scintigraphy may be valuable not only for evaluating hepatic function before hepatectomy for HCC but also for assessing the aggressive biology of a tumor.
PATIENTS AND METHODS: In total, 115 patients who underwent 99mTc-GSA scintigraphy before hepatectomy for HCC were included in this study. Tumor radioactivity in 99mTc-GSA scintigraphy was assessed, and its prognostic relevance to disease-free survival (DFS) and overall survival (OS) in patients with HCC was evaluated.
RESULTS: The hepatic uptake index in 99mTc-GSA scintigraphy was associated with liver fibrosis. HCC with high tumor radioactivity in 99mTc-GSA scintigraphy showed high expression of the asialoglycoprotein receptor. Tumor radioactivity in 99mTc-GSA scintigraphy was associated with histologic differentiation grade and tumor size. Low tumor radioactivity was identified as an independent poor prognostic predictor of both DFS and OS.
CONCLUSIONS: 99mTc-GSA scintigraphy may be valuable not only for evaluating hepatic function before hepatectomy for HCC but also for assessing the aggressive biology of a tumor.