Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019
Efficacy of ulipristal acetate (UPA) for the treatment of expulsion uterine myomas: report of two cases.
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Palaia Innocenza, Del Negro Valentina, Fracassi Alice, Schiavi Michele, Di Donato Violante, Fischetti Margherita, Muzii Ludovico, Benedetti Panici Pierluigi
Аннотация
Expulsion leiomyoma can represent an emergency condition and may lead to severe vaginal hemorrhage with anemia and urgent hysterectomy. Among medical treatments used for leiomyoma, Selective progesterone receptor modulators (SPRM) and, in particular, Ulipristal Acetate (UPA) have been proved to be effective in the management of bleeding and myoma size reduction. However, to our knowledge, there are no cases reported in literature on the use of UPA used as 'emergency' medical therapy in patients with severe anemia and vaginal bleeding due to expulsion leiomyoma. In this paper we would report two cases of patients affected by expulsion myoma successfully treated with UPA with immediate resolution of vaginal bleeding and subsequent elective conservative treatment.