Polypoidal Choroidal Vasculopathy Based on Non-ICGA Criteria in White Patients With Neovascular Age-Related Macular Degeneration.
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Chaikitmongkol Voraporn, Ozimek Malgorzata, Srisomboon Titipol, Patikulsila Direk, Fraser-Bell Samantha, Chhablani Jay, Choovuthayakorn Janejit, Watanachai Nawat, Kunavisarut Paradee, Rodríguez-Valdés Patricio J, Lozano-Rechy David, Lupidi Marco, Al-Sheikh Mayss, Fung Adrian T, Busch Catharina, Mehta Hemal, Gabrielle Pierre-Henry, Zur Dinah, Ramon Dan, Sangkaew Apisara, Ingviya Thammasin, Amphornprut Atchara, Cebeci Zafer, Couturier Aude, Mendes Thais Sousa, Giancipoli Ermete, Iglicki Matias, Invernizzi Alessandro, Lains Ines, Rehak Matus, Sala-Puigdollers Anna, Okada Mali, Loewenstein Anat, Bressler Neil M
Аннотация
METHODS: A total of 208 treatment-naive eyes from Hispanic and non-Hispanic White individuals diagnosed with nAMD were included. All underwent color fundus photography (CFP), optical coherence tomography (OCT), and fluorescein angiography (FFA). De-identified images of study eyes were sent to 2 groups of graders. Group 1 reviewed CFP, OCT, and FFA to confirm nAMD diagnosis. Group 2 reviewed CFP and OCT to determine highly suggestive features for PCV. Probable PCV diagnosis defined as the presence of ≥2 of 4 highly suggestive features for PCV: notched or fibrovascular pigment epithelial detachment (PED) on CFP, sharply-peaked PED, notched PED, and hyperreflective ring on OCT.
RESULTS: Eleven eyes were excluded because of poor image quality (6) or non-nAMD diagnosis (5). Of 197 eligible eyes (197 patients), the mean age (SD) was 78.8 years (8.9), 44.2% were men, 26.4% were Hispanic, and 73.6% were non-Hispanic White individuals; 41.1%, 23.4%, 9.1%, and 2.5% had ≥1, ≥2, ≥3, and 4 highly suggestive features. Results showed that 23.4% (95% CI, 17.6%-29.9%) had probable PCV diagnosis. Predominantly occult CNV was more frequently found in probable PCV than nAMD subgroup (84.8% vs 64.9%, P = .01). Hispanic White individuals had a lower prevalence of probable PCV than non-Hispanic White individuals (9.6% vs 28.2%, P = .006) CONCLUSIONS: These findings suggest that probable PCV occurs between 17.6% and 29.9% in White individuals with nAMD, and more commonly in non-Hispanic than in Hispanic White individuals.