Gut IgA: Never fear, the super inducers are here.

In this issue of Cell Host & Microbe, Zhang et al. show that long-term oral administration of a pectin-derived prebiotic broadly enhanced IgA responses to commensals in the small intestine. This effect required T cells and involved Lachnospiraceae A2, suggesting that a few symbionts promote IgA responses to many commensals.