Annals of medicine and surgery (2012) · 2025
Clinicopathological and molecular mechanisms of cribriform morular thyroid carcinoma: a case report and a literature review.
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Zhang Xi, Lv Yuanshi, Yan Wendi, Lu Hongzhi, Jin Hui, Gao Hong
Аннотация
INTRODUCTION AND IMPORTANCE: Cribriform morular thyroid carcinoma (CMTC) is a rare malignant thyroid carcinoma, mainly seen in young Asian women. CMTC is related to the activation of the WNT/β-catenin signaling pathway, so CMTC is usually closely related to familial adenomatous polyposis (FAP).
CASE PRESENTATION: The patient was a 13-year-and-11-month-old girl with a right neck mass. After total thyroidectomy and bilateral lymph node dissection, the tumor's pathological report is CMTC, and 31 lymph nodes exhibited metastatic carcinoma. Adenomatous polyposis coli (APC) gene mutation has been detected.
CLINICAL DISCUSSION: CMTC has typical cribriform and morular structures under microscope. It is associated with the WNT/β-catenin signaling pathway through inactivating mutations in the APC, CTNNB1, and AXIN1 genes, thereby enabling WNT gene expression and participating in proliferation, invasion, dedifferentiation, and tumorigenesis.
CONCLUSION: CMTC is usually closely related to FAP. It requires clinical attention, and the patient's intestinal condition still needs to be closely monitored after surgery.
CASE PRESENTATION: The patient was a 13-year-and-11-month-old girl with a right neck mass. After total thyroidectomy and bilateral lymph node dissection, the tumor's pathological report is CMTC, and 31 lymph nodes exhibited metastatic carcinoma. Adenomatous polyposis coli (APC) gene mutation has been detected.
CLINICAL DISCUSSION: CMTC has typical cribriform and morular structures under microscope. It is associated with the WNT/β-catenin signaling pathway through inactivating mutations in the APC, CTNNB1, and AXIN1 genes, thereby enabling WNT gene expression and participating in proliferation, invasion, dedifferentiation, and tumorigenesis.
CONCLUSION: CMTC is usually closely related to FAP. It requires clinical attention, and the patient's intestinal condition still needs to be closely monitored after surgery.