Research square · 2026
From Gestational Age-Specific Serum Creatinine Trajectories to an Interactive Clinical Interpretation Tool in Level IV NICU Infants.
СтатьяПрепринтНазвание и аннотация: Перевод пока не подготовлен
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Rumpel Jennifer, Perazzo Sofia, South Andrew, Bonachea Elizabeth, Khattab Mona, Gillen Matthew, Asante Joseph, Gogcu Semsa, Liu Daniel, Starr Michelle, Nienaber Thomas, Slagle Cara, Brown Clare, Harer Matthew, Najaf Tasnim, Han Rachel, Ray Patricio, Bona Jonathan, Schootman Mario, Nagel Corey
Аннотация
OBJECTIVE: To characterize gestational age (GA)-specific serum creatinine (SCr) trajectories among level IV neonatal intensive care unit (NICU) infants and develop an interactive interpretation tool.
STUDY DESIGN: We analyzed ADVANCE database records linking kidney-specific data with Children's Hospitals Neonatal Consortium clinical data from ten level IV NICUs (2010-2022). Infants with ≥ 1 SCr measurement (DOL 1-365) were included. GA-specific trajectories were generated for DOL 1-28 and week of life 1-16; an interactive tool was developed for clinical use.
RESULT: Among 34,306 infants contributing 390,612 SCr measurements, SCr trajectories differed by GA. Peak SCr ranged from 0.93 mg/dL (IQR 0.80-1.10) at 22-24 weeks' GA (DOL 4) to 0.76 mg/dL (IQR 0.65-0.90) among term infants (DOL 2), declining to a similar nadir (~ 0.20-0.23 mg/dL) across GA groups.
CONCLUSION: SCr trajectories vary by GA and postnatal age in this population. These trajectories and the accompanying tool provide context for interpreting SCr values.
STUDY DESIGN: We analyzed ADVANCE database records linking kidney-specific data with Children's Hospitals Neonatal Consortium clinical data from ten level IV NICUs (2010-2022). Infants with ≥ 1 SCr measurement (DOL 1-365) were included. GA-specific trajectories were generated for DOL 1-28 and week of life 1-16; an interactive tool was developed for clinical use.
RESULT: Among 34,306 infants contributing 390,612 SCr measurements, SCr trajectories differed by GA. Peak SCr ranged from 0.93 mg/dL (IQR 0.80-1.10) at 22-24 weeks' GA (DOL 4) to 0.76 mg/dL (IQR 0.65-0.90) among term infants (DOL 2), declining to a similar nadir (~ 0.20-0.23 mg/dL) across GA groups.
CONCLUSION: SCr trajectories vary by GA and postnatal age in this population. These trajectories and the accompanying tool provide context for interpreting SCr values.