Challenges in Diagnosis and Management of Ovarian Neuroendocrine Carcinoma: A Case of Aggressive Disease With Multimodal Treatment Approach.

Neuroendocrine tumors (NETs) of the ovary are extremely rare, accounting for only 1%-2% of malignant ovarian tumors, with high-grade subtypes demonstrating particularly aggressive behavior. We describe a 47-year-old woman who presented with abdominal swelling, irregular bleeding, and pain, and was diagnosed with high-grade ovarian neuroendocrine carcinoma following surgical resection. Despite initial treatment with paclitaxel and carboplatin, residual disease persisted, prompting therapy with long-acting Sandostatin. The disease subsequently progressed with hepatic and peritoneal involvement, and she was successfully managed with cisplatin and etoposide. This case illustrates the diagnostic complexity and aggressive course of ovarian neuroendocrine carcinoma and underscores the importance of individualized, multimodal treatment strategies and vigilant follow-up in the absence of standardized guidelines.