ACS omega · 2026
Biocompatible Cyclodextrin-Cannabinoid Agar-Xanthan Gum Hydrogels for Controlled Delivery and Antimicrobial Soft-Tissue Biomedical Applications.
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Zamora-Ledezma Camilo, Solano-Orrala Dulexy, Peña-Jimenez Daniel, Herranz-Gómez Sandra, Silva-Cullishpuma Dennis A, Mercader-Ros María Teresa, Gomez d'Ayala Giovanna, Duraccio Donatella, Mowbray Duncan John, Díaz-López Stephanie Marina, Alexis Frank, Lucas-Abellán Carmen
Аннотация
Agar/xanthan hydrogels incorporating hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complexes of nonpsychoactive cannabinoids (cannabidiol, CBD; cannabinol, CBN) were developed as multifunctional biomaterials for controlled delivery and antimicrobial soft-tissue biomedical applications. Physicochemical characterization showed improved thermal stability, tunable hydrophilicity, and a porous network suitable for loading and release. In vitro release studies demonstrated sustained cannabinoid delivery over 72 h, following first-order and Fu-Kao kinetic models. The hydrogels exhibited selective antimicrobial activity against Staphylococcus aureus, while remaining inactive toward Escherichia coli. Cytocompatibility assays with human skin fibroblasts confirmed noncytotoxic behavior over 7 days for all hydrogel formulations tested. These results highlight that cyclodextrin-cannabinoid-loaded agar/xanthan hydrogels are promising biocompatible platforms for controlled delivery with antimicrobial activity, suitable for tissue engineering applications.