Biomarkers in medicine · 2012
Clinical evaluation of human epididymis protein 4 as a biomarker for epididymitis.
Оценочное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Pilatz A, Bürger M, Lüdecke G, Wagenlehner F, Weidner W
Аннотация
AIM: To evaluate HE4 as a potential biomarker for acute epididymitis.
MATERIALS & METHODS: HE4 levels in serum were measured in 62 patients with acute epididymitis and 62 age-matched male controls.
RESULTS: Both patients with epididymitis and the controls showed median HE4 values of 42 pmol/l (range: 10-560 pmol/l) and 34 pmol/l (range: 2-300 pmol/l), respectively (p = 0.3). Levels of HE4 did not change in the course of the treatment in patients with epididymitis. Regression analysis revealed no significant association between HE4 and any infection-linked variable. Multivariate analysis resulted in a number of factors associated with increased HE4 levels, which were renal dysfunction, cardiovascular diseases and malignancies.
CONCLUSION: Although HE4 is not a biomarker for epididymitis and infection, it qualifies as a candidate for identifying patients with increased morbidity.
MATERIALS & METHODS: HE4 levels in serum were measured in 62 patients with acute epididymitis and 62 age-matched male controls.
RESULTS: Both patients with epididymitis and the controls showed median HE4 values of 42 pmol/l (range: 10-560 pmol/l) and 34 pmol/l (range: 2-300 pmol/l), respectively (p = 0.3). Levels of HE4 did not change in the course of the treatment in patients with epididymitis. Regression analysis revealed no significant association between HE4 and any infection-linked variable. Multivariate analysis resulted in a number of factors associated with increased HE4 levels, which were renal dysfunction, cardiovascular diseases and malignancies.
CONCLUSION: Although HE4 is not a biomarker for epididymitis and infection, it qualifies as a candidate for identifying patients with increased morbidity.