Annals of the New York Academy of Sciences · 2015
B cells generated by B-1 development can progress to chronic lymphocytic leukemia.
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Hayakawa Kyoko, Formica Anthony M, Colombo Matthew J, Ichikawa Daiju, Shinton Susan A, Brill-Dashoff Joni, Hardy Richard R
Аннотация
B cells generated early during fetal/neonatal B-1 development in mice include autoreactive cells with detectable CD5 upregulation induced by B cell receptor (BCR) signaling (B1a cells). A fraction of B1a cells are maintained by self-renewal for life, with the potential risk of dysregulated growth and progression to chronic lymphocytic leukemia (CLL)/lymphoma during aging. In studies using the Eμ-hTCL1 transgenic mouse system, it became clear that this B1a subset has a higher potential than other B cell subsets for progression to CLL. We have generated several autoreactive germline BCR gene models to compare B cells generated under conditions of natural exposure to autoantigen. Analysis of the mice has been key in understanding the importance of the BCR and BCR signaling for generating different B cell subsets and for investigating the cellular origin of B-CLL.