Hepato-gastroenterology · 2012
Prognostic predictors of patients with carcinoma of the gastric cardia.
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Zhang Ming, Li Zhigao, Ma Yan, Zhu Guanyu, Zhang Hongfeng, Xue Yingwei
Аннотация
BACKGROUND/AIMS: This study gives insight into survival predictors and clinicopathological features of carcinoma of the gastric cardia.
METHODOLOGY: The study included 233 patients who underwent operation for carcinoma of the gastric cardia. Clinicopathological prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Cox regression was used for multivariate analysis and survival curves were drawn by the Kaplan- Meier method.
RESULTS: Carcinoma of the gastric cardia was characterized by positive lymph node metastasis (77.3%), serosal invasion (83.3%) and more stage III or IV tumors (72.5%). Overall 5-year survival rate was 21.9% and median survival period was 24 months. The 5-year survival rate was influenced by tumor size, depth on invasion, lymph node metastasis, extent of lymph node dissection, disease stage, operation methods and resection margin.
CONCLUSIONS: The absent of serosal invasion and lymph node metastasis, curative resection should be considered to be the favourable predictors of long-term survival of patients with carcinoma of the gastric cardia.
METHODOLOGY: The study included 233 patients who underwent operation for carcinoma of the gastric cardia. Clinicopathological prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Cox regression was used for multivariate analysis and survival curves were drawn by the Kaplan- Meier method.
RESULTS: Carcinoma of the gastric cardia was characterized by positive lymph node metastasis (77.3%), serosal invasion (83.3%) and more stage III or IV tumors (72.5%). Overall 5-year survival rate was 21.9% and median survival period was 24 months. The 5-year survival rate was influenced by tumor size, depth on invasion, lymph node metastasis, extent of lymph node dissection, disease stage, operation methods and resection margin.
CONCLUSIONS: The absent of serosal invasion and lymph node metastasis, curative resection should be considered to be the favourable predictors of long-term survival of patients with carcinoma of the gastric cardia.
Предметные рубрики MeSH
AdultAgedAged, 80 and overCarcinomaCardiaChinaFemaleGastrectomyHumansKaplan-Meier EstimateLymph Node ExcisionLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsStomach NeoplasmsTime FactorsTreatment Outcome