Zhonghua nan ke xue = National journal of andrology · 2006
[Castration affects the expression of androgen receptor and epidermal growth factor in rat submaxillary salivary gland].
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Zhu Yun-feng
Аннотация
OBJECTIVE: To investigate the effect of castration on the quantity of androgen receptor (AR) and the epidermal growth factor (EGF) in the submaxillary salivary glands of castrated rats.
METHODS: Sixty male Wistar rats, aged 30 to approximately 60 days, were randomly divided into three groups of 20 rats: castrated, sham-operated and normal control (unoperated). The submaxillary salivary glands of the castrated rats were removed one week after surgery, and so were those of the rats in the sham-operated and the normal control groups. The homogenized salivary gland was used for Western-blots.
RESULTS: The quantity of AR and EGF in the submaxillary salivary glands was decreased significantly in the castrated rats compared with that in the sham-operated and the normal control ( P < 0. 05). Moreover, EGF secreted by the submaxillary salivary glands was also decreased in the castrated rats (P < 0.05).
CONCLUSION: Castration affected the production of androgen receptor in the salivary gland, and also, could further affect the secretion of EGF from the salivary gland.
METHODS: Sixty male Wistar rats, aged 30 to approximately 60 days, were randomly divided into three groups of 20 rats: castrated, sham-operated and normal control (unoperated). The submaxillary salivary glands of the castrated rats were removed one week after surgery, and so were those of the rats in the sham-operated and the normal control groups. The homogenized salivary gland was used for Western-blots.
RESULTS: The quantity of AR and EGF in the submaxillary salivary glands was decreased significantly in the castrated rats compared with that in the sham-operated and the normal control ( P < 0. 05). Moreover, EGF secreted by the submaxillary salivary glands was also decreased in the castrated rats (P < 0.05).
CONCLUSION: Castration affected the production of androgen receptor in the salivary gland, and also, could further affect the secretion of EGF from the salivary gland.