Nature genetics · 2011
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
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Shi Yongyong, Hu Zhibin, Wu Chen, Dai Juncheng, Li Huizhang, Dong Jing, Wang Meilin, Miao Xiaoping, Zhou Yifeng, Lu Feng, Zhang Hanze, Hu Lingmin, Jiang Yue, Li Zhiqiang, Chu Minjie, Ma Hongxia, Chen Jiaping, Jin Guangfu, Tan Wen, Wu Tangchun, Zhang Zhengdong, Lin Dongxin, Shen Hongbing
Аннотация
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
Предметные рубрики MeSH
AMP-Activated Protein KinasesAdultAgedCase-Control StudiesChromosomes, Human, Pair 3Chromosomes, Human, Pair 5FemaleGenetic LociGenome-Wide Association StudyHumansMaleMiddle AgedNerve Tissue ProteinsOdds RatioPolymorphism, Single NucleotideReceptors, Prostaglandin E, EP4 SubtypeStomach NeoplasmsTranscription Factors