Evidence-based complementary and alternative medicine : eCAM · 2023
Hypokinetic Activity of Menthofuran on the Gastrointestinal Tract in Rodents.
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Santos Railson de Sousa, Nunes Paulo Humberto Moreira, Lima Geovanni de Morais, Brito Ana Karolinne da Silva, Pacheco James Frederico Rocha, Medina Heldemys da Costa, Benigno Maria Ivone Mendes, de Sousa Damião Pergentino, de Moura-Filho Oseas Florêncio, Cunha Francisco Valmor Macedo, Reis Renandro de Carvalho, Oliveira Rita de Cássia Meneses, Arcanjo Daniel Dias Rufino, Martins Maria do Carmo de Carvalho E
Аннотация
The acute toxicity and hypokinetic activity induced by menthofuran on the gastrointestinal tract of rodents were investigated in the present study. An absence of acute toxicity was observed. Menthofuran delayed gastric emptying at oral doses of 25, 50, and 100 mg/kg in the experimental model of phenol red, as well as it reduced the intestinal transit at oral doses of 50 and 100 mg/kg. Interestingly, a scopolamine-similar hypokinetic effect was observed for menthofuran. In the experimental model of castor oil-induced intestinal hypermotility, menthofuran (50 and 100 mg/kg) reduced the number of loose stools as observed for the normal group. Additionally, menthofuran induced a marked concentration-dependent relaxation in rat ileum segments precontracted with KCl (EC50 = 0.059 ± 0.008 μg/mL) or carbachol (EC50 = 0.068 ± 0.007 μg/mL). These results suggest the possible decrease of calcium influx underlying the effects of menthofuran on the gastrointestinal tract, which opens the door for further study regarding this potential application for the treatment of gastrointestinal disorders, noting possible limitations of its use due to adverse effects in children.