Spectrum of clinical manifestations of familial adenomatous polyposis.

Familial adenomatous polyposis is an autosomal dominant disease that primarily involves the colon, but may involve other organs such as the central nervous system, ampulla of Vater, liver, soft tissue and the remainder of the gastrointestinal tract. In this report we present the adenocarcinoma of the uterus and adenocarcinoma of the ovary as a new addition to the clinical spectrum of familial adenomatous polyposis. Due to the tendency for development of multiple primary carcinomas in patients with familial adenomatous polyposis, these patients need to be followed very closely for detection of new malignancies. If diagnosed early and treated accordingly, they could have a long-term postoperative survival.