Heart, lung & circulation · 2025
Fluorodeoxyglucose Positron Emission Tomography Detects Persistent Arterial Inflammation After Symptomatic COVID-19.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Espedal Heidi, Verma Shipra, Roy Ambuj, Lan Nick S R, Mohd Sheeraz, Bartlett Benjamin, Ali Kamar, Ward Natalie C, Ebert Martin A, Chan Dick C, Watts Gerald F, Dwivedi Girish, Francis Roslyn J
Аннотация
BACKGROUND: There is limited knowledge of persisting vascular and systemic inflammation in adults recovered from COVID-19. This study aimed to assess whether inflammation from symptomatic mild-to-moderate COVID-19 persists beyond the apparent clinical resolution of disease using fluorodeoxyglucose positron emission tomography (FDG-PET).
METHOD: This observational single-centre cohort study invited adults (aged >40 years) who had clinically recovered from mild-to-moderate COVID-19. Whole-body FDG-PET imaging and C-reactive protein test were performed on the same day after a minimum of 30 days after COVID-19 diagnosis. COVID-19-naive adults at high-risk for cardiovascular disease (CVD) were included for comparison (n=8); thoracic FDG-PET imaging was performed for these participants.
RESULTS: FDG-PET imaging was performed after a median of 97 days (interquartile range [IQR] 75-113 days) after COVID-19 diagnosis. Participants who recovered from COVID-19 showed an increased arterial inflammation (median standard uptake value [SUV]max 3.1; IQR 2.7-3.3) compared with the high-risk participants with CVD (median SUVmax 2.5; IQR 2.2-2.8; p<0.001). There was a moderate positive correlation between the total thoracic SUVmax and the bone marrow SUVmean (Spearman r=0.58; p<0.001) and the spleen mean SUVmax (Spearman r=0.62, p<0.001) for participants who recovered from COVID-19.
CONCLUSIONS: Ongoing arterial inflammation is detected by FDG-PET imaging after mild-to-moderate COVID-19. Larger prospective studies are needed to assess the implications on CVD risk.
METHOD: This observational single-centre cohort study invited adults (aged >40 years) who had clinically recovered from mild-to-moderate COVID-19. Whole-body FDG-PET imaging and C-reactive protein test were performed on the same day after a minimum of 30 days after COVID-19 diagnosis. COVID-19-naive adults at high-risk for cardiovascular disease (CVD) were included for comparison (n=8); thoracic FDG-PET imaging was performed for these participants.
RESULTS: FDG-PET imaging was performed after a median of 97 days (interquartile range [IQR] 75-113 days) after COVID-19 diagnosis. Participants who recovered from COVID-19 showed an increased arterial inflammation (median standard uptake value [SUV]max 3.1; IQR 2.7-3.3) compared with the high-risk participants with CVD (median SUVmax 2.5; IQR 2.2-2.8; p<0.001). There was a moderate positive correlation between the total thoracic SUVmax and the bone marrow SUVmean (Spearman r=0.58; p<0.001) and the spleen mean SUVmax (Spearman r=0.62, p<0.001) for participants who recovered from COVID-19.
CONCLUSIONS: Ongoing arterial inflammation is detected by FDG-PET imaging after mild-to-moderate COVID-19. Larger prospective studies are needed to assess the implications on CVD risk.