The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
Three-Decade Analysis of Inflammatory Bowel Disease in Türkiye: A Multicenter Study (1993-2024).
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Durak Muhammed Bahaddin, Cagin Yasir Furkan, Balkan Ayhan, Coskun Yusuf, Karakan Tarkan, Cagir Yavuz, Beyazit Yavuz, Atay Ali, Erdem Ali Can, Can Guray, Altinkaya Engin, Dursun Hakan, Coskun Orhan, Ayte Mehmet Rasit, Hamamci Mevlut, Tenlik Ilyas, Simsek Cem, Sahin Abdurrahman, Koseoglu Huseyin, Akar Mustafa, Kosar Kenan, Albayrak Bulent, Karatay Eylem, Kekilli Murat, Asil Mehmet, Ataseven Hilmi, Cindoruk Mehmet, Yuksel Ilhami
Аннотация
BACKGROUND/AIMS: Inflammatory bowel diseases (IBDs) are increasingly prevalent and challenging globally. Data regarding IBD frequency and severity between Europe and Asia are needed. The aim was to investigate the trend of IBD in Türkiye during the last 3 decades.
MATERIALS AND METHODS: The study was conducted retrospectively at 14 centers in Türkiye between June 1993 and March 2024.
RESULTS: Over 30 years, 4308 patients, of whom 2507 (58.2%) had ulcerative colitis (UC) and 1717 (39.9%) had Crohn's Disease (CD), were included in the study. The overall median age at the onset of IBD was 34.43 (25.28-45.64) years; the age at onset of IBD was younger in CD compared to UC (32.72 vs. 35.52 years respectively, P < .001). The peak age onset range was 28-32 years in CD, whereas 23-27 years in UC. Overall, 2526 (58.6%) patients were male. The most common location was left-sided colitis in UC patients (45.1%), followed by extensive colitis (31.2%), and proctitis (23.7%), while ileal involvement in CD patients (45.2%), afterward ileocolonic (409%), and colonic (13.5%). Both illnesses are becoming increasingly prevalent. The UC/CD ratio tends to decrease over time. During the study period, 1577 (36.6%) patients received biologic treatment. During the study period, 418 (24.3%) underwent resective surgery for CD and 88 (3.5%) total colectomy for UC; the major abdominal surgery has declined over time.
CONCLUSION: The frequency and characteristic features of IBD in Türkiye appear to be between Europe and Asia. Over time, while the usage of biologic therapy and the rate of CD have increased, the frequency of surgery has decreased.
MATERIALS AND METHODS: The study was conducted retrospectively at 14 centers in Türkiye between June 1993 and March 2024.
RESULTS: Over 30 years, 4308 patients, of whom 2507 (58.2%) had ulcerative colitis (UC) and 1717 (39.9%) had Crohn's Disease (CD), were included in the study. The overall median age at the onset of IBD was 34.43 (25.28-45.64) years; the age at onset of IBD was younger in CD compared to UC (32.72 vs. 35.52 years respectively, P < .001). The peak age onset range was 28-32 years in CD, whereas 23-27 years in UC. Overall, 2526 (58.6%) patients were male. The most common location was left-sided colitis in UC patients (45.1%), followed by extensive colitis (31.2%), and proctitis (23.7%), while ileal involvement in CD patients (45.2%), afterward ileocolonic (409%), and colonic (13.5%). Both illnesses are becoming increasingly prevalent. The UC/CD ratio tends to decrease over time. During the study period, 1577 (36.6%) patients received biologic treatment. During the study period, 418 (24.3%) underwent resective surgery for CD and 88 (3.5%) total colectomy for UC; the major abdominal surgery has declined over time.
CONCLUSION: The frequency and characteristic features of IBD in Türkiye appear to be between Europe and Asia. Over time, while the usage of biologic therapy and the rate of CD have increased, the frequency of surgery has decreased.