Ai zheng = Aizheng = Chinese journal of cancer · 2005
[Expression of S100-labeled dendritic cells in glottic squamous cell carcinoma and its correlation to prognosis].
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Chen Wen-Kuan, Chen Fu-Jin, Zeng Zong-Yuan, Wu Guo-Hao, Guo Zhu-Ming, Wei Mao-Wen, Yang An-Kui, Zhang Quan, He Jie-Hua, Hou Jing-Hui
Аннотация
BACKGROUND & OBJECTIVE: Dendritic cells (DCs) are the most important antigen-presenting cells, and can synthesize and secrete S100 protein. This study was designed to investigate the expression of S100-labeled DCs in glottic squamous cell carcinoma, and analyze its correlation to the prognosis.
METHODS: The expression of S100-labeled DCs in peritumoral tissues of 111 specimens of gllotic squamous cell carcinoma was detected by immunohistochemistry; 17 specimens of normal tissues were used as control. The correlation of S100-labeled DCs expression to prognosis of the 111 patients was evaluated.
RESULTS: The positive rates of S100-labeled DCs were 51.35% (57/111) in peritumoral tissues of gllotic squamous cell carcinoma, and 0 in normal tissues. The 5-year survival rate was significantly higher in S100-positive group than in S100-negative group (72.31% vs. 53.91%, P=0.030).
CONCLUSIONS: The glottic squamous cell carcinoma patients with obvious infiltration of S100-labeled DCs may achieve good prognosis.
METHODS: The expression of S100-labeled DCs in peritumoral tissues of 111 specimens of gllotic squamous cell carcinoma was detected by immunohistochemistry; 17 specimens of normal tissues were used as control. The correlation of S100-labeled DCs expression to prognosis of the 111 patients was evaluated.
RESULTS: The positive rates of S100-labeled DCs were 51.35% (57/111) in peritumoral tissues of gllotic squamous cell carcinoma, and 0 in normal tissues. The 5-year survival rate was significantly higher in S100-positive group than in S100-negative group (72.31% vs. 53.91%, P=0.030).
CONCLUSIONS: The glottic squamous cell carcinoma patients with obvious infiltration of S100-labeled DCs may achieve good prognosis.