Internal medicine (Tokyo, Japan) · 2021
Endobronchial Lesions from Disseminated Mycobacterium avium Infection in a Patient with Anti-interferon-gamma Autoantibodies.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Mochizuka Yasutaka, Kono Masato, Hirama Ryutaro, Oshima Yuiko, Takeda Kenichiro, Tsutsumi Akari, Miwa Hideki, Miki Yoshihiro, Hashimoto Dai, Kimura Toshiki, Sakagami Takuro, Nakamura Hidenori
Аннотация
A 78-year-old man was admitted to our hospital with a fever and left chest pain. Computed tomography showed multiple lung nodules, narrowing of the right bronchus intermedius with mediastinal lymphadenopathy, and an osteolytic lesion. Bronchoscopic findings showed rapid progression of multiple polypoid lesions and the bronchial stenosis. A biopsy of the endobronchial lesions revealed non-necrotizing granulomatous inflammation, and a tissue culture identified Mycobacterium avium. An anti-human immunodeficiency virus antibody was negative. Finally, anti-interferon-gamma (IFN-γ) autoantibodies were detected, and the patient was diagnosed with disseminated nontuberculous mycobacterium infection with anti-IFN-γ autoantibodies. Antimycobacterial therapy was effective, and radiographic findings, including the endobronchial lesions, were resolved.