Zhonghua nei ke za zhi · 2009
[A meta-analysis of thymoma-associated systemic lupus erythematosus from 1975 - 2008 worldwide].
Аннотация на английскомСтатьяМетаанализПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zhang Lu, Dong Jie, Leng Xiao-Mei, Zeng Xiao-Feng
Аннотация
OBJECTIVE: To investigate the clinical features and treatment strategy for the thymoma-associated systemic lupus erythematosus (SLE) in a worldwide perspective.
METHODS: All articles between 1975 to 2008 were searched with the key words "SLE Thymoma" or "SLE thymectomy" in the database of Pubmed & Medline; the Chinese articles were searched with the same key words in the database of China Hospital Knowledge Database (CHKD). Data were extracted and analyzed.
RESULTS: 44 patients from 24 studies were available for this analysis with a male-to-female ratio of 1: 6. The mean age of SLE onset was 47.9 (21-76) while the mean age of discovery of thymoma was 48.5 (18-77). The clinical picture of SLE was classical with no statistical difference between genders. However, the thymoma-associated SLE occurs in patients older than the classical onset age of SLE (P < 0.01). As for treatment, the glucocorticoids-based immune-suppressive therapy still proves to be effective (P < 0.01). The thymoma could be benign or invasive which does not depend on gender or age. There is no statistical difference with regards to pathologic sub-types. As for the patients who already had SLE when discovering the thymoma, the clinical outcomes varied after the thymectomy (remission 27.8%, exacerbation 33.3%, no change 38.9%, P > 0.05).
CONCLUSION: The possibility of thymoma should be considered among those late-onset SLE patients. The glucocorticoid-based immunosuppressive therapy is effective for thymoma-associated SLE. To treat SLE is not an indication for thymectomy.
METHODS: All articles between 1975 to 2008 were searched with the key words "SLE Thymoma" or "SLE thymectomy" in the database of Pubmed & Medline; the Chinese articles were searched with the same key words in the database of China Hospital Knowledge Database (CHKD). Data were extracted and analyzed.
RESULTS: 44 patients from 24 studies were available for this analysis with a male-to-female ratio of 1: 6. The mean age of SLE onset was 47.9 (21-76) while the mean age of discovery of thymoma was 48.5 (18-77). The clinical picture of SLE was classical with no statistical difference between genders. However, the thymoma-associated SLE occurs in patients older than the classical onset age of SLE (P < 0.01). As for treatment, the glucocorticoids-based immune-suppressive therapy still proves to be effective (P < 0.01). The thymoma could be benign or invasive which does not depend on gender or age. There is no statistical difference with regards to pathologic sub-types. As for the patients who already had SLE when discovering the thymoma, the clinical outcomes varied after the thymectomy (remission 27.8%, exacerbation 33.3%, no change 38.9%, P > 0.05).
CONCLUSION: The possibility of thymoma should be considered among those late-onset SLE patients. The glucocorticoid-based immunosuppressive therapy is effective for thymoma-associated SLE. To treat SLE is not an indication for thymectomy.