Internal medicine (Tokyo, Japan) · 2009
Durable hypogammaglobulinemia associated with thymoma (Good syndrome).
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kitamura Atsushi, Takiguchi Yuichi, Tochigi Naobumi, Watanabe Shun-ichi, Sakao Seiichirou, Kurosu Katsushi, Tanabe Nobuhiro, Tatsumi Koichiro
Аннотация
Good syndrome, characterized by hypogammaglobulinemia and acquired immunodeficiency, is a rare condition associated with thymoma. A 67-year-old woman, who 4 months previously had a thymoma resected, presented with generalized hypogammaglobulinemia with a severely decreased B cell population as demonstrated by flow cytometry. She was diagnosed as having bacterial mediastinitis associated with Good syndrome. For the subsequent 6 years, she suffered from repeated serious bacterial infections. As this paraneoplastic syndrome is not resolved by tumor removal, careful management with intensive infection-control using antibiotics and intravenous immunoglobulins is required for the long term. Serum immunoglobulin levels should be evaluated for patients with thymoma and suspected vulnerability to infection.