Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2012
Histomorphometric analysis of the effects of creatine on rat myometrium.
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Do Amaral Vinícius Cestari, Simões Manuel De Jesus, Marcondes Rodrigo Rodrigues, Matozinho Cubas Jairo José, Baracat Edmund Chada, Soares José Maria
Аннотация
OBJECTIVE: To analyze the myometrial thickness of rats subjected to creatine (Cr) ingestion.
STUDY DESIGN: A total of 14 rats was equally divided into the control group (ConGr) receiving 1 ml potable water and the creatine group (CrGr) subjected to the ingestion of 1.6 g/kg Cr diluted in 1 ml potable water. At the end of 8 weeks, the animals were anesthetized (xylazine and ketamine) and sacrificed, the uteri and ovaries stained with hematoxylin and eosin, the thickness of both the myometrium and the epithelium measured and the follicles counted.
RESULTS: Analysis revealed a significant increase in thickness of the myometrium in the CrGr (272.26 ± 66.71μm) contrasted with that from the ConGr (160.76 ± 35.65μm), CrGr > ConGr (p < 0001).
CONCLUSION: Our data suggest that Cr changed myometrial morphology in rats by enhancing myometrial thickness, but its action mechanism in the smooth muscle is still unclear.
STUDY DESIGN: A total of 14 rats was equally divided into the control group (ConGr) receiving 1 ml potable water and the creatine group (CrGr) subjected to the ingestion of 1.6 g/kg Cr diluted in 1 ml potable water. At the end of 8 weeks, the animals were anesthetized (xylazine and ketamine) and sacrificed, the uteri and ovaries stained with hematoxylin and eosin, the thickness of both the myometrium and the epithelium measured and the follicles counted.
RESULTS: Analysis revealed a significant increase in thickness of the myometrium in the CrGr (272.26 ± 66.71μm) contrasted with that from the ConGr (160.76 ± 35.65μm), CrGr > ConGr (p < 0001).
CONCLUSION: Our data suggest that Cr changed myometrial morphology in rats by enhancing myometrial thickness, but its action mechanism in the smooth muscle is still unclear.