Clinical Phenotype and Disease Course of Inflammatory Bowel Disease in Iran: Results of the Iranian Registry of Crohn's and Colitis (IRCC).
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Saberzadeh-Ardestani Bahar, Khosravi Amir Ali, Mansour-Ghanaei Fariborz, Vahedi Homayoon, Baniasadi Nadieh, Seyyedmajidi Mohammadreza, Parhizkar Baran, Hormati Ahmad, Naghshbandi Sayed Jalalledin, Matin Somaieh, Hassan Zadeh Amir Abbas, Taghvaei Tarang, Bahrami Mohsen, Rafeey Mandana, Ahadi Mitra, Vossoughinia Hassan, Muosavi Hashem, Gheibi Shahsanam, Hosseini-Hemmatabadi Roya-Sadat, Yazdanbod Abbas, Matinkhah Saied, Sheikh Esmaeili Farshad, Fakheri Hafez, Moosavy Seyed Hamid, Maleki Iradj, Nasseri-Moghaddam Siavosh, Khosravi Bardia, Farahmand Fatemeh, Najafi Mehri, Alimadadi Hosein, Malekzadeh Masoud, Anushiravani Amir, Kasaeian Amir, Alatab Sudabeh, Sadeghi Anahita, Radmard Amir Reza, Kolahdoozan Shadi, Rajabi Zeynab, Sima Ali Reza
Аннотация
METHODS: We conducted a cross-sectional study of registered IBD patients in the Iranian Registry of Crohn's and Colitis (IRCC) from 2017 until 2022. We collected information on demographic characteristics, past medical history, family history, disease extent and location, extra-intestinal manifestations, IBD medications, and activity using the IBD-control-8 questionnaire and the Manitoba IBD index, admissions history, history of colon cancer, and IBD-related surgeries.
RESULTS: In total, 9746 patients with ulcerative colitis (UC) (n=7793), and Crohn's disease (CD) (n=1953) were reported. The UC to CD ratio was 3.99. The median age at diagnosis was 29.2 (IQR: 22.6,37.6) and 27.6 (IQR: 20.6,37.6) for patients with UC and CD, respectively. The male-to-female ratio was 1.28 in CD patients. A positive family history was observed in 17.9% of UC patients. The majority of UC patients had pancolitis (47%). Ileocolonic involvement was the most common type of involvement in CD patients (43.7%), and the prevalence of stricturing behavior was 4.6%. A prevalence of 0.3% was observed for colorectal cancer among patients with UC. Moreover,15.2% of UC patients and 38.4% of CD patients had been treated with anti-tumor necrosis factor (anti-TNF).
CONCLUSION: In this national registry-based study, there are significant differences in some clinical phenotypes such as the prevalence of extra-intestinal manifestations and treatment strategies such as biological use in different geographical locations.