Arthroplasty (London, England) · 2025
Inflammatory-induced swelling after total knee arthroplasty: Obesity and preoperative joint pain as key predictors.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yang Lin, Zhan Yi-Fang, Zhai Zan-Jing, Zhang Shi-Zhen, Wang Cai-Feng, Li Qun, Wu Bei-Ying, Bian Wei-Wei, Li Hui-Wu, Ruan Hong
Аннотация
OBJECTIVE: Limited research exists on factors influencing early postoperative swelling after total knee arthroplasty (TKA). This prospective observational cohort study aims to analyze patterns and predictors of early postoperative inflammatory swelling following TKA, informing high-risk screening and interventions.
METHODS: This study measured 110 TKA patients' (76.4% female, mean age 69.51 ± 7.46 years) lower limb circumference (10 cm/5 cm above patella, patella, calf, ankle) preoperatively and postoperatively 1-5 days. Variables of interest included body mass index (BMI), preoperative joint pain, postoperative joint and thigh pain, cryotherapy duration, and inflammatory biomarkers.
RESULTS: Swelling peaked proximally at 5 cm above the patella on day 3 (4.16 ± 2.90 cm). Multivariable regression analysis identified BMI as a core predictor of lower limb swelling (P < 0.05), with a 1-unit increase in BMI corresponding to a 0.18-0.24 cm increase in proximal leg circumference. Pain timing was site-specific: swelling 10 cm above the patella was associated with preoperative joint pain on touch (β = 0.184, P = 0.052), calf swelling with postoperative joint pain at rest (β = 0.213, P = 0.022), and ankle swelling with postoperative thigh pain at rest (β = 0.228, P = 0.017). Other factors and inflammatory markers were not significantly associated with swelling (P > 0.05). However, preoperative joint pain during activity correlated with higher white blood cell (WBC) counts (P = 0.012), and postoperative thigh resting pain with elevated C-reactive protein (CRP) levels (P = 0.035).
CONCLUSION: Early postoperative proximal swelling following TKA warrants attention, as chronic pro-inflammatory states in obese patients and the progression of knee osteoarthritis lead to elevated inflammatory levels, exacerbating postoperative swelling. Focus should be placed on high-risk patients with obesity and preoperative joint pain on touch.
TRIAL REGISTRATION: ChiCTR2500098167. Video Abstract.
METHODS: This study measured 110 TKA patients' (76.4% female, mean age 69.51 ± 7.46 years) lower limb circumference (10 cm/5 cm above patella, patella, calf, ankle) preoperatively and postoperatively 1-5 days. Variables of interest included body mass index (BMI), preoperative joint pain, postoperative joint and thigh pain, cryotherapy duration, and inflammatory biomarkers.
RESULTS: Swelling peaked proximally at 5 cm above the patella on day 3 (4.16 ± 2.90 cm). Multivariable regression analysis identified BMI as a core predictor of lower limb swelling (P < 0.05), with a 1-unit increase in BMI corresponding to a 0.18-0.24 cm increase in proximal leg circumference. Pain timing was site-specific: swelling 10 cm above the patella was associated with preoperative joint pain on touch (β = 0.184, P = 0.052), calf swelling with postoperative joint pain at rest (β = 0.213, P = 0.022), and ankle swelling with postoperative thigh pain at rest (β = 0.228, P = 0.017). Other factors and inflammatory markers were not significantly associated with swelling (P > 0.05). However, preoperative joint pain during activity correlated with higher white blood cell (WBC) counts (P = 0.012), and postoperative thigh resting pain with elevated C-reactive protein (CRP) levels (P = 0.035).
CONCLUSION: Early postoperative proximal swelling following TKA warrants attention, as chronic pro-inflammatory states in obese patients and the progression of knee osteoarthritis lead to elevated inflammatory levels, exacerbating postoperative swelling. Focus should be placed on high-risk patients with obesity and preoperative joint pain on touch.
TRIAL REGISTRATION: ChiCTR2500098167. Video Abstract.