Pakistan journal of medical sciences · 2025
Effects of sentinel lymph node biopsy combined with breast-conserving surgery on surgical-related indexes, serum TPA level and recurrence rate in patients with early breast cancer.
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Gong Ke, Yang Siqi, Liu Youzhong, Xu Yong
Аннотация
OBJECTIVE: To explore the effects of sentinel lymph node biopsy (SLNB) combined with breast-conserving surgery on surgical-related indexes, serum tissue polypeptide antigen (TPA) level and recurrence rate in patients with early breast cancer.
METHODS: This was retrospective study. A total of 112 patients with early breast cancer who underwent surgical treatment in The First People's Hospital of Changde City from January 2020 to January 2024 were enrolled. According to different surgical methods, they were divided into control group (49 cases, modified radical mastectomy) and observation group (63 cases, SLNB combined with breast-conserving surgery). The perioperative indexes, levels of serum tumor markers, postoperative complications, long-term survival and recurrence were compared between the two groups.
RESULTS: The operation time, intraoperative blood loss, postoperative drainage volume, hospitalization time in observation group were significantly lower than those in control group (P<0.05). Before surgery and at three months after surgery, there were no significant differences in the levels of serum cancer antigen 153(CA153), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) between the two groups(P>0.05). After three years of follow-up, there were no significant differences in the recurrence rate and survival rate between the two groups (P>0.05).
CONCLUSION: Compared with modified radical mastectomy, SLNB combined with breast-conserving surgery may have better surgical procedures and outcomes, and significantly reduce the incidence of upper limb edema. The effects of surgical method choice are fewer on the long-term prognosis and postoperative levels of tumor markers such as serum TPA.
METHODS: This was retrospective study. A total of 112 patients with early breast cancer who underwent surgical treatment in The First People's Hospital of Changde City from January 2020 to January 2024 were enrolled. According to different surgical methods, they were divided into control group (49 cases, modified radical mastectomy) and observation group (63 cases, SLNB combined with breast-conserving surgery). The perioperative indexes, levels of serum tumor markers, postoperative complications, long-term survival and recurrence were compared between the two groups.
RESULTS: The operation time, intraoperative blood loss, postoperative drainage volume, hospitalization time in observation group were significantly lower than those in control group (P<0.05). Before surgery and at three months after surgery, there were no significant differences in the levels of serum cancer antigen 153(CA153), carcinoembryonic antigen (CEA), and tissue polypeptide antigen (TPA) between the two groups(P>0.05). After three years of follow-up, there were no significant differences in the recurrence rate and survival rate between the two groups (P>0.05).
CONCLUSION: Compared with modified radical mastectomy, SLNB combined with breast-conserving surgery may have better surgical procedures and outcomes, and significantly reduce the incidence of upper limb edema. The effects of surgical method choice are fewer on the long-term prognosis and postoperative levels of tumor markers such as serum TPA.