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Войти в исследования Clinical rheumatology · 2026
Urate-lowering therapy adherence among gout patients in Southwest China: A cross-sectional study of determinants and regional disparities.
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Tang Zhenboyang, Huang Chunyan, Qiu Guangqiang, Wei Guangliang, Ling Xiru, Wu Jiqiang, Wang Ping, Chen Jie
Аннотация
OBJECTIVE: Gout is directly associated with hyperuricemia. This study aims to investigate the adherence rate to urate-lowering therapy (ULT) and its influencing factors among patients with gout in Southwest China.
METHODS: A cross-sectional study was conducted involving 1023 gout patients treated at the Affiliated Hospital of Southwest Medical University between January 2022 and June 2025. Data were collected through telephone follow-ups and electronic medical record reviews. The Adherence to Refills and Medications Scale (ARMS) was used to assess ULT adherence among gout patients. A multivariate binary logistic regression model was used to analyze the correlation between independent variables.
RESULTS: The ULT adherence rate among gout patients was 31.6%. Multivariate binary logistic regression analysis revealed that smoking and alcohol consumption were independently associated with poor ULT adherence. Concurrent hypertension, concurrent diabetes, frequency of follow-up visits (> 3 times/year), confidence in maintaining serum uric acid within the normal range, awareness that the target serum uric acid level for ULT is 360 μmol/L, awareness that urate-lowering drugs should be taken long-term, and awareness that increased low-fat dairy intake benefits gout treatment were independently associated with good ULT adherence.
CONCLUSION: Adherence to ULT in Southwest China remains suboptimal but is higher than previously reported rates in other Chinese regions. We identified several modifiable factors-particularly disease knowledge, follow-up frequency, and lifestyle habits-that represent actionable targets for interventions to improve gout management in this underserved population. Key Points • The current status of ULT adherence among gout patients is suboptimal, and no existing surveys have examined ULT adherence rates among gout patients in Southwest China. • Our research findings indicated that the ULT adherence rate among gout patients was 31.6%. • Smoking and alcohol consumption were negatively associated with ULT adherence, whereas comorbid hypertension, diabetes, follow-up frequency exceeding three times per year, confidence, and gout-related knowledge were positively associated with improved ULT adherence.
METHODS: A cross-sectional study was conducted involving 1023 gout patients treated at the Affiliated Hospital of Southwest Medical University between January 2022 and June 2025. Data were collected through telephone follow-ups and electronic medical record reviews. The Adherence to Refills and Medications Scale (ARMS) was used to assess ULT adherence among gout patients. A multivariate binary logistic regression model was used to analyze the correlation between independent variables.
RESULTS: The ULT adherence rate among gout patients was 31.6%. Multivariate binary logistic regression analysis revealed that smoking and alcohol consumption were independently associated with poor ULT adherence. Concurrent hypertension, concurrent diabetes, frequency of follow-up visits (> 3 times/year), confidence in maintaining serum uric acid within the normal range, awareness that the target serum uric acid level for ULT is 360 μmol/L, awareness that urate-lowering drugs should be taken long-term, and awareness that increased low-fat dairy intake benefits gout treatment were independently associated with good ULT adherence.
CONCLUSION: Adherence to ULT in Southwest China remains suboptimal but is higher than previously reported rates in other Chinese regions. We identified several modifiable factors-particularly disease knowledge, follow-up frequency, and lifestyle habits-that represent actionable targets for interventions to improve gout management in this underserved population. Key Points • The current status of ULT adherence among gout patients is suboptimal, and no existing surveys have examined ULT adherence rates among gout patients in Southwest China. • Our research findings indicated that the ULT adherence rate among gout patients was 31.6%. • Smoking and alcohol consumption were negatively associated with ULT adherence, whereas comorbid hypertension, diabetes, follow-up frequency exceeding three times per year, confidence, and gout-related knowledge were positively associated with improved ULT adherence.