Zhonghua bing li xue za zhi = Chinese journal of pathology · 2016
[Expression and significance of HGAL and LMO2 in follicular lymphoma].
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Zhang Fen, Luo Donglan, Luo Xinlan, Chen Yu, Xu Jie, Chen Jie, Zhuang Hengguo, Liu Yanhui
Аннотация
OBJECTIVE: To evaluate the diagnostic value of HGAL and LMO2 expression and compare with CD10 and bcl-6 in follicular lymphoma (FL).
METHODS: 63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.
RESULTS: The expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4% (62/63), 82.5% (52/63), 82.5% (52/63) and 87.3% (55/63), respectively. The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant (P>0.05). There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases. The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases(P<0.01).
CONCLUSIONS: HGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.
METHODS: 63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.
RESULTS: The expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4% (62/63), 82.5% (52/63), 82.5% (52/63) and 87.3% (55/63), respectively. The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant (P>0.05). There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases. The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases(P<0.01).
CONCLUSIONS: HGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.