Journal of the American Academy of Dermatology · 1996
IgG anti-50 kd lymphocyte membrane peptide antibody in patients with Sézary syndrome.
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D'Ambra-Cabry K, Tharp M D, Jagasothy B V, Deng J S
Аннотация
BACKGROUND: Recent evidence suggests that as cutaneous T-cell lymphoma progresses, cell-mediated immunity is reduced and humoral responses are augmented.
OBJECTIVE: The present study was designed to compare the IgG response in Sézary syndrome with that in mycosis fungoides.
METHODS: The IgG antilymphocyte response was studied in six patients with Sézary syndrome and in 11 patients with mycosis fungoides by means of immunoblot analysis, enzyme-linked immunosorbent assay, immunohistochemistry, and flow cytometry.
RESULTS: An IgG antilymphocyte response to a 50 kd peptide was seen in five of the six patients with Sézary syndrome; however, none of the 11 patients with mycosis fungoides expressed this response.
CONCLUSIONS: An enhanced IgG immune response to 50 kd lymphocyte peptide may be helpful in identifying disease progression in patients with cutaneous T-cell lymphoma.
OBJECTIVE: The present study was designed to compare the IgG response in Sézary syndrome with that in mycosis fungoides.
METHODS: The IgG antilymphocyte response was studied in six patients with Sézary syndrome and in 11 patients with mycosis fungoides by means of immunoblot analysis, enzyme-linked immunosorbent assay, immunohistochemistry, and flow cytometry.
RESULTS: An IgG antilymphocyte response to a 50 kd peptide was seen in five of the six patients with Sézary syndrome; however, none of the 11 patients with mycosis fungoides expressed this response.
CONCLUSIONS: An enhanced IgG immune response to 50 kd lymphocyte peptide may be helpful in identifying disease progression in patients with cutaneous T-cell lymphoma.