American journal of ophthalmology · 2007
Ocular involvement as the initial manifestation of T-cell chronic lymphocytic leukemia.
Клинический случайСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Calfa Carmen J, Lossos Izidore S, Ruiz Phillip, Davis Janet L
Аннотация
PURPOSE: To present a case of T-cell chronic lymphocytic leukemia (T-CLL) manifesting as an intraocular lymphoma.
DESIGN: Interventional case report.
METHODS: We performed a vitreous biopsy in a 67-year-old woman who presented with blurred vision and vitreous cellular infiltration. Morphologic, immunohistochemical, flow cytometry, and molecular analysis by polymerase chain reaction of vitreous fluid, peripheral blood, bone marrow aspirate, and biopsy were performed.
RESULTS: Cytofluorographic and molecular analysis of vitreous cells demonstrated a monoclonal T-cell population consistent with a T-cell intraocular lymphoma. Systemic evaluation established diagnosis of T-cell CLL.
CONCLUSION: T-CLL is a rare disease with an aggressive clinical course. We present a case of T-cell intraocular lymphoma as the initial manifestation of an otherwise asymptomatic T-CLL.
DESIGN: Interventional case report.
METHODS: We performed a vitreous biopsy in a 67-year-old woman who presented with blurred vision and vitreous cellular infiltration. Morphologic, immunohistochemical, flow cytometry, and molecular analysis by polymerase chain reaction of vitreous fluid, peripheral blood, bone marrow aspirate, and biopsy were performed.
RESULTS: Cytofluorographic and molecular analysis of vitreous cells demonstrated a monoclonal T-cell population consistent with a T-cell intraocular lymphoma. Systemic evaluation established diagnosis of T-cell CLL.
CONCLUSION: T-CLL is a rare disease with an aggressive clinical course. We present a case of T-cell intraocular lymphoma as the initial manifestation of an otherwise asymptomatic T-CLL.
Предметные рубрики MeSH
AgedAntibiotics, AntineoplasticBiomarkers, TumorBiopsyBone Marrow CellsDNA, NeoplasmDiagnosis, DifferentialEye NeoplasmsFemaleFlow CytometryFluorescein AngiographyFollow-Up StudiesFundus OculiHumansImmunohistochemistryLeukemia, Prolymphocytic, T-CellLymphoma, T-Cell, PeripheralPentostatinPolymerase Chain ReactionTomography, Optical CoherenceVitrectomyVitreous Body