Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2007
Primary ocular natural killer/T-cell lymphomas: clinicopathologic features and diagnosis.
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Yang Yuli, Luo Qingli, He Weiming, Tang Li
Аннотация
PURPOSE: Primary ocular natural killer/T-cell lymphoma (NKTL) is rare. This study aims to characterize the clinical manifestations, diagnosis and treatment methods of primary ocular NKTL.
METHODS: Clinical data of seven patients with ocular NKTL from 1982 to 2004 were collected. A morphologic, immunohistochemical and molecular analysis was undertaken.
RESULTS: Clinical manifestations and computed tomography of the patients were typical. LCA CD56 CD3epsilon Ki-67 granzyme B (GrB) and T-cell intracellular antigen-1(TIA-1) were mostly positive. Clonal T-cell-receptor gene rearrangements of five patients showed negative findings, and the detection of Epstein-Barr virus showed positive. All patients died 5 months to 28 months after presentation.
CONCLUSION: Ocular NKTL is a highly aggressive clinical course with poor prognosis. The diagnosis relies on clinicopathologic findings.
METHODS: Clinical data of seven patients with ocular NKTL from 1982 to 2004 were collected. A morphologic, immunohistochemical and molecular analysis was undertaken.
RESULTS: Clinical manifestations and computed tomography of the patients were typical. LCA CD56 CD3epsilon Ki-67 granzyme B (GrB) and T-cell intracellular antigen-1(TIA-1) were mostly positive. Clonal T-cell-receptor gene rearrangements of five patients showed negative findings, and the detection of Epstein-Barr virus showed positive. All patients died 5 months to 28 months after presentation.
CONCLUSION: Ocular NKTL is a highly aggressive clinical course with poor prognosis. The diagnosis relies on clinicopathologic findings.
Предметные рубрики MeSH
AdultBiomarkers, TumorCD3 ComplexCD56 AntigenCombined Modality TherapyDNA, NeoplasmDiagnosis, DifferentialFollow-Up StudiesGenes, T-Cell Receptor gammaGranzymesHumansImmunohistochemistryKi-67 AntigenKiller Cells, NaturalLymphoma, T-Cell, PeripheralMagnetic Resonance ImagingMaleOrbital NeoplasmsPoly(A)-Binding ProteinsPolymerase Chain ReactionPrognosisT-Cell Intracellular Antigen-1Tomography, X-Ray Computed