Reply to Shilpa Gupta, Maria Carmen Mir, and Daniel E. Spratt's Letter to the Editor re: Riccardo Bertolo, Antonio Luigi Pastore, Paolo Verze, et al. Real-world Burden and Management of Late Genitourinary Toxicity after Prostate Radiotherapy: Insights from IRRADIaTE, the Italian Registry of Radiotherapy-associated Disorders and Urological Treatment & Evaluation. Eur Urol Oncol. 2026;9:408-416. http://dx.doi.org/10.1016/j.euo.2026.01.005.