Scientific reports · 2023
Microcalcification crystallography as a potential marker of DCIS recurrence.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Gosling Sarah B, Arnold Emily L, Davies Samantha K, Cross Hannah, Bouybayoune Ihssane, Calabrese Doriana, Nallala Jayakrupakar, Pinder Sarah E, Fu Liping, Lips Esther H, King Lorraine, Marks Jeffrey, Hall Allison, Grimm Lars J, Lynch Thomas, Pinto Donna, Stobart Hilary, Hwang E Shelley, Wesseling Jelle, Geraki Kalotina, Stone Nicholas, Lyburn Iain D, Greenwood Charlene, Rogers Keith D, Grand Challenge PRECISION Consortium
Аннотация
Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.