Emerging infectious diseases · 2012
Transmission routes for nipah virus from Malaysia and Bangladesh.
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Clayton Bronwyn A, Middleton Deborah, Bergfeld Jemma, Haining Jessica, Arkinstall Rachel, Wang Linfa, Marsh Glenn A
Аннотация
Human infections with Nipah virus in Malaysia and Bangladesh are associated with markedly different patterns of transmission and pathogenicity. To compare the 2 strains, we conducted an in vivo study in which 2 groups of ferrets were oronasally exposed to either the Malaysia or Bangladesh strain of Nipah virus. Viral shedding and tissue tropism were compared between the 2 groups. Over the course of infection, significantly higher levels of viral RNA were recovered from oral secretions of ferrets infected with the Bangladesh strain. Higher levels of oral shedding of the Bangladesh strain of Nipah virus might be a key factor in onward transmission in outbreaks among humans.