Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2015
Outcome analysis of 215 patients with parotid gland tumors: a retrospective cohort analysis.
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Erovic Boban M, Shah Manish D, Bruch Guillem, Johnston Meredith, Kim John, O'Sullivan Brian, Perez-Ordonez Bayardo, Weinreb Ilan, Atenafu Eshetu G, de Almeida John R, Gullane Patrick J, Brown Dale, Gilbert Ralph W, Irish Jonathan C, Goldstein David P
Аннотация
BACKGROUND: To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital.
METHODS: Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period.
RESULTS: Two-hundred-fifteen patients with adenoid cystic carcinoma (n = 20), adenocarcinoma (n = 19), acinic cell carcinoma (n = 62), basal cell adenocarcinoma (n = 7), carcinoma-ex-pleomorphic adenoma (n = 18), mucoepidermoid carcinoma (n = 70) and salivary duct carcinoma (n = 19) have been included. The 5- and 10-year overall and disease-free survivals were 80.62%/69.48% and 74.37%/62.42%, respectively. Multivariable analysis showed that age greater than 60 years, advanced pN classification, histopathological grade and the presence of lymphovascular invasion significantly worsened overall and disease-free survival. Univariable analysis revealed periparotid lymph node involvement was associated with decreased overall (p < 0.0001) and disease-free survival (p < 0.0001).
CONCLUSIONS: In addition to age, pN classification, histopathological grade, perineural invasion, and lymphovascular involvement, periparotid lymph node metastasis appears to be an important prognosticator in parotid gland malignancy.
METHODS: Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period.
RESULTS: Two-hundred-fifteen patients with adenoid cystic carcinoma (n = 20), adenocarcinoma (n = 19), acinic cell carcinoma (n = 62), basal cell adenocarcinoma (n = 7), carcinoma-ex-pleomorphic adenoma (n = 18), mucoepidermoid carcinoma (n = 70) and salivary duct carcinoma (n = 19) have been included. The 5- and 10-year overall and disease-free survivals were 80.62%/69.48% and 74.37%/62.42%, respectively. Multivariable analysis showed that age greater than 60 years, advanced pN classification, histopathological grade and the presence of lymphovascular invasion significantly worsened overall and disease-free survival. Univariable analysis revealed periparotid lymph node involvement was associated with decreased overall (p < 0.0001) and disease-free survival (p < 0.0001).
CONCLUSIONS: In addition to age, pN classification, histopathological grade, perineural invasion, and lymphovascular involvement, periparotid lymph node metastasis appears to be an important prognosticator in parotid gland malignancy.