Internal medicine (Tokyo, Japan) · 2025
High-grade and Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas with STK11 Aberration Having Undergone Pancreatic Resection Three Times for Metachronous Intrapancreatic Recurrences: A Case Report and Review of the Literature.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Anan Hideyuki, Koshita Shinsuke, Kanno Yoshihide, Ogawa Takahisa, Kusunose Hiroaki, Sakai Toshitaka, Yonamine Keisuke, Miyamoto Kazuaki, Kozakai Fumisato, Okano Haruka, Hosokawa Kento, Oikawa Masaya, Tsuchiya Takashi, Noda Yutaka, Sawai Takashi, Itoh Taito, Omori Yuko, Furukawa Toru, Ito Kei
Аннотация
A 56-year-old woman with high-grade or invasive intraductal papillary mucinous neoplasm (IPMN) underwent 3 pancreatic surgeries for initial and recurrent IPMN lesions. Immunostaining and genetic analyses of all lesions revealed a consistent mutation in KRAS and loss of serine/threonine kinase 11 (STK11), indicating the same origin of these lesions and the possibility of intraductal dissemination. Other immunostaining findings, such as mucin expression and a high Ki-67 labeling index, were consistent among all the lesions and supported their malignant potential. IPMNs with loss of STK11 may benefit from tailored follow-up of the remnant pancreas due to their high likelihood of recurrence through intraductal spread.