Real-world Experience with Volume Augmentation using Cohesive Polydensified Matrix Hyaluronic Acid Gel: A Retrospective Single-center Analysis of 110 Consecutive Patients with Medium- to Long-term Follow-up.

Objective: Hyaluronic acid (HA) volumizer injection into subcutaneous and deep tissue layers is increasingly used for nonsurgical volume loss correction. Information on optimal techniques, safety, and medium- to long-term satisfaction is limited. This study evaluated cohesive polydensified matrix® HA volumizer CPM-26 (Modélis® Shape or Belotero® Volume) across different indications. Design: This study was a retrospective chart review and included a patient questionnaire given at six months posttreatment and during long-term assessment (mean: 3.2 years). Setting: This study was conducted in a Belgian single-site plastic surgery practice. Participants: Consecutive patients (n=110, aged 19-74 years, 81% female) receiving single/ multiple injections with CPM-26 between 2010 and 2016 were included. Measurements: Procedural details and safety outcomes, patient estimates of satisfaction and adverse events, and Global Aesthetic Improvement Scale (GAIS) score were considered. Results: Participants received 601 injections over 189 sessions. The most common sites for volumizing injection were the lateral midface, deep prejowl sulcus, and anterior midface. In six participants, the injection site was the penis (8, 1.3%). Questionnaire data were provided by 81 patients. At six months, 94.9 percent (74/78) were satisfied with outcomes, while, at long-term assessment (mean: 3.2 years), 74.9 percent (54/73) were satisfied. Conclusion: Deep CPM-26 injection improved appearance and was reported as beneficial by two-thirds of patients at long-term assessment. Local adverse events were minor, transient, and infrequently required treatment.