Longitudinal radiological follow-up of individual level non-ischemic cerebral enhancing lesions following endovascular aneurysm treatment.
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Guetarni Zakaria, Bernard Remy, Boulouis Grégoire, Labeyrie Marc-Antoine, Biondi Alessandra, Velasco Stéphane, Saliou Guillaume, Bartolini Bruno, Daumas-Duport Benjamin, Bourcier Romain, Janot Kevin, Herbreteau Denis, Michelozzi Caterina, Premat Kevin, Redjem Hocine, Escalard Simon, Bricout Nicolas, Thouant Pierre, Arteaga Charles, Pierot Laurent, Tahon Florence, Boubagra Kamel, Ikka Leon, Chabert Emmanuel, Lenck Stephanie, Guédon Alexis, Consoli Arturo, Saleme Suzana, Forestier Géraud, Di Maria Federico, Ferré Jean-Christophe, Anxionnat René, Eugene Francois, Kerleroux Basile, Dargazanli Cyril, Sourour Nader-Antoine, Clarençon Frédéric, Shotar Eimad
Аннотация
OBJECTIVE: To evaluate the radiological behavior of individual NICE lesions over time.
METHODS: Patients included in a retrospective national multicentric inception cohort were analyzed. NICE lesions were defined, using MRI, as delayed onset punctate, nodular, or annular foci enhancements with peri-lesion edema, distributed in the vascular territory of the aneurysm treatment, with no other confounding disease. Lesion burden and the longitudinal behavior of individual lesions were assessed.
RESULTS: Twenty-two patients were included, with a median initial lesion burden of 36 (IQR 17-54) on the first MRI scan. Of the 22 patients with at least one follow-up MRI scan, 16 (73%) had new lesions occurring mainly within the first 200 weeks after the date of the procedure. The median number of new lesions per MRI was 6 (IQR 2-16). Among the same 22 patients, 7 (32%) had recurrent lesions. The median persistent enhancement of a NICE lesion was 13 weeks (IQR 6-30). No factor was predictive of early regression of enhancement activity with lesion regression kinetics mainly being patient-dependent.
CONCLUSIONS: The behavior of individual NICE lesions was found to be highly variable with an overall patient-dependent regression velocity.