[Platelet membrane glycoprotein defect, molecular basis for the abnormal adhesion of platelets to the subendothelium in thrombocytic hemorrhagic dystrophy].

A large reduction in the staining capacity of a glycoprotein of 155 000 M.W. was observed in the platelets of 2 macrogiant platelets syndrome patients, associated with a reduced platelet adhesion to rabbit aorta subendothelium and with the presence of von Willebrand protein on these platelets as revealed by an antihuman factor VIII-Von Willebrand protein rabbit antibody. These results led the authors to propose a strong hypothesis on the role of this glycoprotein rich in sialic acid - in platelet adhesion to subendothelium.