Safety and efficacy of a feed additive consisting of l-isoleucine produced with Corynebacterium glutamicumCGMCC 32505 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd).

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l-isoleucine produced by fermentation with Corynebacterium glutamicum CGMCC 32505 as a nutritional additive in feed or water for drinking for all animal species and categories. The production strain is genetically modified. None of the genetic modifications raised a safety concern. Viable cells or DNA of the production strain were not detected in the final product. The use of l-isoleucine produced with C. glutamicum CGMCC 32505 in feed was considered safe for the target species when supplemented in appropriate amounts to the diet according to the nutritional needs. The FEEDAP Panel had concerns on the use of amino acids in water for drinking. The use of l-isoleucine (≥ 98.0%) produced with C. glutamicum CGMCC 32505 in animal nutrition was considered safe for the consumers and the environment. Regarding the safety for the user, owing to the lack of data, the FEEDAP Panel cannot conclude on the potential of the additive to be irritant to skin and/or eyes and to be a potential skin sensitiser. The additive was regarded as an effective source of the amino acid l-isoleucine for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.